The VDR gene FokI polymorphism is associated with gestational diabetes mellitus in Turkish women

BMC Medical Genetics

Mustafa Ulubay¹  Mahmut Apaydın²  Erman Cakal²  Muhammed Kizilgul²  Mustafa Caliskan²  Selvihan Beysel³  Ferda Alparslan Pinarli⁴  Nilnur Eyerci⁴  Ozhan Ozdemir⁵ 

[1] 0000 0001 0720 6034, grid.413460.4, Department of Obstetrics and Gynecology, Gulhane School of Medicine, Ankara, Turkey;0000 0004 0419 0366, grid.413698.1, Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey;0000 0004 0419 0366, grid.413698.1, Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey;0000 0001 1457 1144, grid.411548.d, Department of Medical Biology, Baskent University, Ankara, Turkey;0000 0004 0419 0366, grid.413698.1, Department of Genetic Research, Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey;0000 0004 0642 7670, grid.413791.9, Department of Obstetrics and Gynecology, Ankara Numune Teaching and Research Hospital, Ankara, Turkey;

关键词: VDR gene;    FokI;    Gestational diabetes;   

DOI  :  10.1186/s12881-019-0820-0

来源: publisher

【 摘 要 】

BackgroundThe association between the vitamin D receptor (VDR) gene and gestational diabetes mellitus (GDM) has not been investigated in Turkish pregnant women. We aimed to investigate associations between VDR gene BsmI (rs15444410), ApaI (rs7975232), FokI (rs19735810), and TaqI (rs731236) single nucleotide polymorphisms (SNPs) and GDM.Material-methodsThis case-control study comprised 100 women with GDM and 135 pregnant women without GDM. The VDR polymorphism was evaluated using Sanger-based DNA sequencing.ResultVDR gene ApaI, BsmI, and TaqI SNPs did not differ between women with and without GDM (each, p > 0.05). ApaI, BsmI, and TaqI were not associated with GDM risk. The VDR gene FokI CT/TT genotype was associated with an increased GDM risk (CT vs. CC, OR = 1.84, 95% CI: [1.05–3.23], p = 0.031; TT vs. CC, OR = 3.95, 95% CI: [1.56–9.96], p = 0.002; CT/TT vs. CC, OR = 2.29, 95% CI: [1.35–3.89], p = 0.002; and CT/CC vs. TT, OR = 3.02, 95% CI: [1.23–7.38], p = 0.012). The FokI-TT genotype was more associated with younger age and higher glucose, HbA1c, and HOMA-IR than the CC and CT genotype. FokI-T was positively correlated with log-HOMA-IR (r = 0.326, p = 0.004). FokI SNPs were independently associated with GDM after adjusting for BMI and age (β = 1.63, 95% CI: [1. 2-4.2], p = 0.012). There were no associations between the FokI, ApaI, BsmI and TaqI haplotypes and GDM.ConclusionVDR gene FokI SNPs were independently associated with having GDM in Turkish women. VDR gene FokI SNPs might contribute to insulin resistance of developing GDM.

【 授权许可】

CC BY