Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Clinical Epigenetics

Teng Huang¹  Jun Zhou¹  Zhenxing Huang¹  Jiying Zhong¹  Sen Lin¹  Meijuan Liao¹  Huan Jing²  Simin Tang³ 

[1] 0000 0004 0604 5998, grid.452881.2, Department of Anesthesiology, The First People’s Hospital of Foshan, 528000, Foshan, Guangdong Province, China;0000 0004 0604 5998, grid.452881.2, Department of Anesthesiology, The First People’s Hospital of Foshan, 528000, Foshan, Guangdong Province, China;0000 0001 0240 6969, grid.417409.f, ZunYi Medical University, 563100, ZunYi, China;0000 0004 0604 5998, grid.452881.2, Department of Anesthesiology, The First People’s Hospital of Foshan, 528000, Foshan, Guangdong Province, China;0000 0001 2360 039X, grid.12981.33, Sun Yet-sen University, 510000, Guangzhou, Guangdong Province, China;

关键词: lncRNAs;    Neuropathic pain;    Spinal cord injury;    Peripheral nerve injury;    Central nerve injury;   

DOI  :  10.1186/s13148-019-0671-8

来源: publisher

【 摘 要 】

Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the mechanisms of NP, clinical practice is still not satisfactory. Fortunately, progress in elucidating unique features and multiple molecular mechanisms of long non-coding RNAs (lncRNAs) in NP has emerged in the past 10 years, suggesting that novel therapeutic strategies for pain treatment may be proposed. In this review, we will concentrate on recent studies associated with lncRNAs in NP. First, we will describe the alterations of lncRNA expression after spinal cord injury (SCI) and peripheral nerve injury (PNI), and then we illustrate the role of some specific lncRNAs in detail, which may offer new insights into our understanding of the etiology and pathophysiology of NP. Finally, we put special emphasis on the altered expression of lncRNAs in the diverse biological process of NP. Recent advances we summarized above in the development of NP may facilitate translation of these findings from bench to bedside in the future.

【 授权许可】

CC BY