Osteopontin – a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease

Journal of Enzyme Inhibition and Medicinal Chemistry

Elena Claudia Coculescu¹  Gheorghe Manole²  Gabi Valeriu Dincă³  Bogdan-Ioan Coculescu⁴  Cristina Mariana Stocheci⁵  Cristina Berteanu⁶ 

[1] Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;Faculty of General Nursing, Bioterra University, Bucharest, Romania;Clinical Hospital Colentina, Bucharest, Romania;Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania;Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania;Center for Military Medical Scientific Research, Bucharest, Romania;Faculty of General Nursing, Bioterra University, Bucharest, Romania;Faculty of Sciences, University of Pitesti, Pitesti, Romani;Neolife Clinic, Bucharest, Romania;

关键词: Osteopontin (OPN);    diastolic heart failure (DHF);    preserved ejection fraction;    biomarker;   

DOI  :  10.1080/14756366.2019.1587418

来源: publisher

【 摘 要 】

The study analyses the significance of the plasmatic values of the OPN dosed to 91 people suffering from diastolic cardiac dysfunction with preserved ejection fraction, thus revealing significant growths of its level compared to the normal value. Despite being a clinical research, its conclusions are a breakthrough, differing from the results of other studies published in the relevant medical literature. We can make this assertion because this study analyses the clinical information given by the circulating values of the OPN, based on experimental models (animals), or on patients with congestive heart failure, which can be identified with the existence of a low systolic flow. The results of our study allow us to assert that the plasmatic values of this glycoprotein lead to its acceptance in the medical practice as a new biomarker that provides indicators regarding the stratification of risk with the patients suffering from heart failure of the diastolic dysfunction type, but whose systolic flow is preserved.

【 授权许可】

CC BY