Determination and diagnostic value of CA9 mRNA in peripheral blood of patients with oral leukoplakia

Journal of Enzyme Inhibition and Medicinal Chemistry

Alejandro Lorenzo Pouso¹  Abel García García¹  Cintia Chamorro Petronacci¹  Manuel Torres López¹  Mario Pérez Sayáns¹  Pilar Gándara Vila¹  Francisco Barros Angueira² 

[1] Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain;Unidad de Medicina Molecular – Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta 2, Hospital Clinico Universitario, Santiago de Compostela, Spai;

关键词: CA9 oral squamous cell carcinoma leukoplakia;   

DOI  :  10.1080/14756366.2018.1466120

来源: publisher

【 摘 要 】

Background: Oral leukoplakia is one of the most common oral premalignant disorder. The classical evaluation through tissue biopsy is not always valid to evaluate the risk of malignization.Material and methods: RT-qPCR was performed on 47 blood samples (21 patients with leukoplakia, 2 with oral squamous cell carcinoma (OSCC), and 24 healthy patients) and on 11 tissue samples (3 leukoplakia, 4 OSCC, and 4 samples of healthy tissue).Results: There are significant differences in expression between the different groups (F = 4.057, p = .006). The Duncan post hoc test shows that the only group that differentiates is the tumour tissue. Using Wilcoxon test, different covariables of patients with leukoplakia were analysed with respect to the group of healthy patients and no significant differences were observed.Conclusions: The diagnostic route through liquid biopsy has not been conclusive in this study, but there are significant differences in the levels analysed in the different tissue samples.

【 授权许可】

CC BY