Comparative study on the predictability of statistical models (RSM and ANN) on the behavior of optimized buccoadhesive wafers containing Loratadine and their in vivo assessment

Drug Delivery

Prithviraj Chakraborty¹  Amitava Ghosh¹  Debarupa D. Chakraborty¹  Versha Parcha² 

[1] Bengal College of Pharmaceutical Sciences and Research, West Bengal University of Technology, B.R.B. Sarani, Durgapur, West Bengal, India an;S. Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, Indi;

关键词: ANN;    buccoadhesive;    in vivo;    Loratadine;    optimization;    RSM;    wafer;   

DOI  :  10.3109/10717544.2014.930759

来源: publisher

【 摘 要 】

Objective: Buccoadhesive wafer dosage form containing Loratadine is formulated utilizing Formulation by Design (FbD) approach incorporating sodium alginate and lactose monohydrate as independent variable employing solvent casting method.Methods: The wafers were statistically optimized using Response Surface Methodology (RSM) and Artificial Neural Network algorithm (ANN) for predicting physicochemical and physico-mechanical properties of the wafers as responses. Morphologically wafers were tested using SEM. Quick disintegration of the samples was examined employing Optical Contact Angle (OCA).Results: The comparison of the predictability of RSM and ANN showed a high prognostic capacity of RSM model over ANN model in forecasting mechanical and physicochemical properties of the wafers. The in vivo assessment of the optimized buccoadhesive wafer exhibits marked increase in bioavailability justifying the administration of Loratadine through buccal route, bypassing hepatic first pass metabolism.

【 授权许可】

Unknown