Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line

Food and Agricultural Immunology

Reena Parida¹  Swagatika Dash¹  Sanghamitra Nayak¹  Shikha Singh¹  Monalisa Ray¹  K. Gopinath Achary² 

[1] Centre for Biotechnology, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, Indi;Imgenex India Pvt Ltd, Bhubaneswar, Odisha, Indi;

关键词: Curcuma longa;    Kaempferia galanga;    Zingiber officinale;    CBMCs;    neonatal cytokines;    immunostimulation;   

DOI  :  10.1080/09540105.2017.1376039

来源: publisher

【 摘 要 】

Edible medicinal plants Curcuma longa, Kaempferia galanga and Zingiber officinale are considered to be suitable for pregnant mother and neonates. Their essential oils are claimed to have therapeutic effects, yet its immunomodulatory activities need to be investigated. To validate the immunomodulatory effect, cord blood monocyte cells (CBMCs) treated with different concentrations of essential oils ranging from 0 to 40 µg/ml. K. galanga oil at 40 µg/ml concentrations upregulated IFN-γ at 49.23 pg/ml, while C. longa oil downregulated the IL-10 at 10.45 pg/ml showing immunostimulant activity on CBMCs. However, Z. officinale oil showed no significant result at any concentration. K. galanga and C. longa oils also showed an increase in lymphocyte proliferation in a dose-dependent manner. The present study was aimed to evaluate the immunomodulatory potentialities of essential oils which will attract the interest of researchers and pharmaceutical industries for clinical studies and other applications in the therapy of diseases related to neonatal infections.

【 授权许可】

CC BY