High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

eLife

Hyung Jin Choi¹  Young Jae Lee²  Ji-Young Cha²  Jung-Wan Kim³  Carmen J Booth⁴  Joong-Hyuck Auh⁵  Cheolsoo Choi⁶  Dae Ho Lee⁶  Sun Wook Cho⁷  Young Joo Park⁷  Kyong Soo Park⁷  Yun Jae Jung⁸  Seung-Soon Im⁹  Yun-Shin Jung^1,10  Jinku Kang^1,10  Byung-Chul Oh^1,10  Jinwook Lee^1,10  Ok-Hee Kim^1,10  Woo Jin Jung^1,10  June Hur^1,10  Hyeonjin Kim^1,11  Jun-Young Yang^1,12  Han Seok Choi^1,13  Young-Bum Kim^1,14  Cheol Soon Lee^1,15 

[1] Department of Anatomy, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute Gachon University College of Medicine, Incheon, Republic of Korea;Department of Biology, University of Incheon, Incheon, Republic of Korea;Department of Comparative Medicine, Yale University School of Medicine, New Haven, United States;Department of Food Science and Technology, Chung-Ang University, Ansung, Republic of Korea;Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Mirobiolgy, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea;Department of Physiology, Keimyung University School of Medicine, Daegu, Republic of Korea;Department of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Republic of Korea;Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Toxicological Evaluation and Research, Ministry of Food and Drug Safety, Cheongju-si, Republic of Korea;Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea;Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, United States;Medical Health Research Center, Korea University Anam Hospital, Seoul, Republic of Korea;

关键词: phytate;    phosphate overload;    kidney stones;    hypophosphatemia;    crystal nephropathies;    calcium;    Rat;   

DOI  :  10.7554/eLife.52709

来源: publisher

【 摘 要 】

Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and of negligible nutritional value in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+ and phosphate absorption and homeostasis are unknown. Here, we show that excessive intake of phytate along with a low-Ca2+ diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+ supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+ bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+ diet and is a risk factor for phosphate overloading and for the development of crystal nephropathies and bone disease.

【 授权许可】

CC BY