Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Oxidative Medicine and Cellular Longevity

Hong Zhang¹  Ke Li²  Yuan-ping Wang²  Jing Zhao²  Ling-zhi Niu²  Ming-xuan Wang²  Ya-juan Zheng² 

[1]Department of Ophthalmology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China, jlu.edu.cn

[2]Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China, jlu.edu.cn

DOI  :  10.1155/2020/9410952

来源: publisher

【 摘 要 】

Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.

【 授权许可】

Unknown