Synthesis of 5,6-Dihydropyridin-2(1H)-ones, 1,5,6,8,8a-Hexa-hydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-Hexahydro-quinolin-2(1H)-ones by Intramolecular Wittig Reaction

Molecules

Alexander S. Fisyuk¹ 

关键词: 5;    6-dihydropyridin-2(1H)-one;    Wittig reaction;    intramolecular cyclization;    N-(3-oxoalkyl)chloroacetamide;   

DOI  :  10.3390/70200124

来源: mdpi

【 摘 要 】

A new, universal and diastereospecific method has been developed for the synthesis of 5,6-dihydropyridin-2(1H)-ones, 1,5,6,8,8a-hexahydroisoquinolin-3(2H)-ones and 4a,5,6,7,8,8a-hexahydroquinolin-2(1H)-ones (4) based on the intramolecular Wittig cyclization of the triphenyphosphonium salts 2 derived from the N-(3-oxoalkyl)–chloroacetamides 1.

【 授权许可】

Unknown   
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