Reactivity of 3-Ethoxycarbonyl Isoquinolinium Salts Towards Various Nucleophilic Reagents: Applications to the Synthesis of New 1,2-Dihydroisoquinoline-3-carboxylates

Molecules

Mohamed Ameziane Aït Amer Meziane¹ 

[1] id="af1-molecules-07-00252">Université de Rennes 1, Institut de Chimie, Synthèse & Electrosynthèses Organiques 3 (SESO 3), UMR-CNRS 6510, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 RENNES Cedex, France. Phone : +(33) 02 23 23 66 03, Fax : +(33) 02 23 23 63

关键词: 1;    2-dihydro isoquinoline;    lipophilic isoquinolinium;    solvent-free quaternization;    organolithium;    alcoholate;    N;    O-acetal;    domino reaction;   

DOI  :  10.3390/70200252

来源: mdpi

【 摘 要 】

Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts. The leaving group character of the isoquinoline moiety was also evidenced.

【 授权许可】

Unknown   
© 2002 by MDPI (http://www.mdpi.org).