Synthesis of Highly Functionalised Enantiopure Bicyclo[3.2.1]- octane Systems from Carvone

Molecules

Antonio Abad¹  Consuelo Agulló¹  Ana C. Cu༚t¹  Ignacio de Alfonso¹  Ismael Navarro¹ 

关键词: carvone;    Diels-Alder reaction;    cyclopropane cleavage;    5-vinyl-1;    3- cyclohexadiene;    samarium diiodide;    bicyclo[3.2.1]octane;    tricyclo[3.2.1.0^2.7]octane;   

DOI  :  10.3390/90500287

来源: mdpi

【 摘 要 】

The commercially available monoterpene carvone has been efficiently converted into the tricyclo[3.2.1.0^2.7]octane and bicyclo[3.2.1]octane systems characteristic of some biologically active compounds. The sequence used for this transformation involves as key features an intramolecular Diels-Alder reaction of a 5-vinyl-1,3-cyclohexadiene and a cyclopropane ring opening.

【 授权许可】

Unknown   
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