Immobilization of 1-[N-(M-Nitrobenzoyl)-α-D,L-Asparagyl]-2- Benzylbenzimidazole on Gellan

Molecules

Marcel Popa²  Valeriu Şunel¹ 

[1] Department of Organic Chemistry “Al.I.Cuza” University of Iaşi, Bd. Carol, no 11, 6600 Iaşi, Romania.;Department of Macromolecules, Faculty of Industrial Chemistry, “Gh.Asachi” Technical University of Iaşi, Bd. D. Mangeron, no 71 A, 6600 Iaşi, Romania.

关键词: Gellan;    polymer-drug system;    controlled release;   

DOI  :  10.3390/80300297

来源: mdpi

【 摘 要 】

This paper studies the dicyclohexylcarbodiimide activated coupling reaction through ester-type covalent bonds of an oxazolone derived from N-(m-nitrobenzoyl)-L-asparagic acid, ring opened with 2-benzylbenzimidazole, on gellan. Based on a centered, rotatory, composed, second order experimental design, the regression equation describing the dependence of the amount of drug chemically bonded to the support on the reaction parameters is obtained. The efficiency of the coupling reaction over the variation domain established is maximum when the parameters’ highest values are used. The kinetics of the drug’s release from the support are studied under alkaline hydrolysis conditions.

【 授权许可】

Unknown   
© 2003 by MDPI (http://www.mdpi.org).