Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

Molecules

René Yves Dumond¹ 

[1] id="af1-molecules-08-00873">DSM Nutritional Products§ R&D Chemical Process Technology, P.O. Box 3255, Bldg. 214/0.61, CH-4002 Basel, Switzerland, Tel. [phone], Fax [phone]

关键词: Polymethylhydrosiloxane (PMHS);    silanes;    ester reduction;    pyridoxine;    vitamin B₆;   

DOI  :  10.3390/81200873

来源: mdpi

【 摘 要 】

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)₂) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B₆, in an overall yield of 38-54 % and a purity of 76%.

【 授权许可】

Unknown   
© 2003 by MDPI (http://www.mdpi.org).