期刊论文详细信息
Molecules | |
Structure-Activity Relationships for the 9-(Pyridin-2’-yl)-aminoacridines | |
Michael D. Mosher1  Kristi L. Holmes2  | |
[1] id="af1-molecules-09-00102">Department of Chemistry, University of Nebraska at Kearney, 905 W. 25th St., Kearney, Nebraska 68849-1150, USA. Tel. +1-(308)-865-8385, Fax +1-(308) 865-83 | |
关键词: Acridine; QSAR; pyridine; DNA; | |
DOI : 10.3390/90300102 | |
来源: mdpi | |
【 摘 要 】
A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing goups on the pyridine ring promoted the interaction with double stranrded DNA.
【 授权许可】
Unknown
© 2004 by MDPI (http:www.mdpi.org).
【 预 览 】
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RO202003190060393ZK.pdf | 158KB | download |