Structure-Activity Relationships for the 9-(Pyridin-2’-yl)-aminoacridines

Molecules

Michael D. Mosher¹  Kristi L. Holmes² 

[1] id="af1-molecules-09-00102">Department of Chemistry, University of Nebraska at Kearney, 905 W. 25^th St., Kearney, Nebraska 68849-1150, USA. Tel. [phone], Fax [phone]

关键词: Acridine;    QSAR;    pyridine;    DNA;   

DOI  :  10.3390/90300102

来源: mdpi

【 摘 要 】

A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing goups on the pyridine ring promoted the interaction with double stranrded DNA.

【 授权许可】

Unknown   
© 2004 by MDPI (http:www.mdpi.org).