Biaryl Product Formation from Cross-coupling in Palladium-catalyzed Borylation of a Boc Protected Aminobromoquinoline Compound

Molecules

Hao Fang¹  Jun Yan¹ 

[1] id="af1-molecules-09-00178">Department of Chemistry, Georgia State University, 33 Gilmer St. S.E., Atlanta, GA 30303 USA. Tel. [phone], Fax [phone]

关键词: Palladium-catalyzed reaction;    Borylation;    Cross-coupling;   

DOI  :  10.3390/90300178

来源: mdpi

【 摘 要 】

The palladium catalyzed borylation of a Boc protected aminobromoquinoline compound with bis(pinacolato)diboron yielded a biaryl compound, resulting from cross coupling, as the major product, instead of the intended boronate, even though no strong base was used. Such results indicate that under certain conditions and with certain substrates, cross coupling can be a major problem during borylation, leading to unintended consequences.

【 授权许可】

Unknown   
© 2004 by MDPI (http:www.mdpi.org).