Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles

Molecules

Alexander A. Bush¹ 

[1] Chemistry Department, Moscow State University, Moscow 119899, Russia

关键词: 5-Nitro-2-pyridone;    oxazolo[3;    2-a]pyridine;    butadiene;    nitrodiene;    aminodiene;    oxazolyldiene;   

DOI  :  10.3390/80600460

来源: mdpi

【 摘 要 】

5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II. These salts II readily react with ammonia and aliphatic amines leading to the products of pyridine ring opening - previously unknown 1-amino-2-nitro-4-(oxazole-2-yl)butadienes-1,3. Reaction of salts II with water lead to hydrolytic cleavage of the oxazole fragment.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.