Solvent and Substituent Effects on the Thermolysis of Antimalarial Fluorophenyl Substituted 1,2.4-Trioxanes

Molecules

Lazaro F. R. Cafferata¹ 

关键词: Peroxides;    Thermolysis;    Fluorophenyl Substituted 1;    2;    4-trioxanes;    Thermal decomposition Reactions;    Solvent and Substituents Effects;    Antimalarial Compounds;   

DOI  :  10.3390/80900655

来源: mdpi

【 摘 要 】

The kinetics and mechanism of the thermal decomposition reaction of cis-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3,3-tetramethylene-l,2,4-trioxacyclo-hexane (I) were investigated separately in n-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 x l0^-5 M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of cis-6-(4-fluorophenyl-5,6-[2-(4-fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated.

【 授权许可】

Unknown   
© 2003 by MDPI (http://www.mdpi.org).