Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents

Molecules

Abdel Kader Mansour¹  Mohga M. Eid¹ 

[1] ¹Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt ²Central Laboratory for Food and Feed, Agricultural Research Centre, 9 El Gamaa St., Giza, Egypt

关键词: Synthesis;    Pyrazoles;    2-Pyrazolines;    Carbohydrazides;   

DOI  :  10.3390/81000744

来源: mdpi

【 摘 要 】

Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10^-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.