Scleroglucan: A Versatile Polysaccharide for Modified Drug Delivery

Molecules

Tommasina Coviello³  Antonio Palleschi²  Mario Grassi¹  Pietro Matricardi³  Gianfranco Bocchinfuso² 

[1] Department of Chemical Engineering, Environment and Raw Materials, University of Trieste, P.le Europa 1, 34127 Trieste, Italy;Department of Sciences and Chemical Technologies, University of Rome “Tor Vergata”, Via de la Ricerca Scientifica, 00133 Rome, Italy;Department of Chemistry and Technology of Biologically Active Compounds, University of Rome “La Sapienza”, P.le Aldo Moro, 00185 Rome, Italy

关键词: Scleroglucan;    Modified release;    Hydrogel.;   

DOI  :  10.3390/10010006

来源: mdpi

【 摘 要 】

Scleroglucan is a natural polysaccharide, produced by fungi of the genus Sclerotium, that has been extensively studied for various commercial applications (secondary oil recovery, ceramic glazes, food, paints, etc.) and also shows several interesting pharmacological properties. This review focuses its attention on the use of scleroglucan, and some derivatives, in the field of pharmaceutics and in particular for the formulation of modified-release dosage forms. The reported investigations refer mainly to the following topics: natural scleroglucan suitable for the preparation of sustained release tablets and ocular formulations; oxidized and crosslinked scleroglucan used as a matrix for dosage forms sensitive to environmental conditions; co-crosslinked scleroglucan/gellan whose delivery rate can be affected by calcium ions. Furthermore, a novel hydrogel obtained with this polysaccharide and borate ions is described, and the particular structure of this hydrogel network has been interpreted in terms of conformational analysis and molecular dynamics. Profound attention is devoted to the mechanisms involved in drug release from the tested dosage forms that depend, according to the specific preparation, on swelling and/or diffusion. Experimental data are also discussed on the basis of a mathematical approach that allows a better understanding of the behavior of the tested polymeric materials.

【 授权许可】

Unknown   
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