Application of the Extended Grunwald-Winstein Equation to Solvolyses of n-Propyl Chloroformate

International Journal of Molecular Sciences

Jin Burm Kyong¹  Hoshik Won¹ 

[1] Department of Chemistry, Hanyang University, Ansan, Kyunggi-Do 425-791, Korea.

关键词: n-Propyl chloroformate;    addition-elimination;    ionization;    solvent isotope effect;    Grunwald-Winstein equation;   

DOI  :  10.3390/i6010087

来源: mdpi

【 摘 要 】

Application of the extended Grunwald-Winstein equation to solvolyses of n‑propyl chloroformate in a variety of pure and binary solvents indicates an addition-elimination pathway in the majority of the solvents but an ionization pathway in the solvents of highest ionizing power and lowest nucleophilicity. For methanolysis, a solvent deuterium isotope effect of 2.17 is compatible with the incorporation of general-base catalysis into the substitution process.  Activation parameters are consistent with the duality of mechanism.  Very modest positive salt effects are observed on adding chloride or bromide salts to the ethanolysis.

【 授权许可】

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