Influence of Long-Tailed Alcohols on the Solubilisation of Cationic DHAB Bilayers

International Journal of Molecular Sciences

Johan A. Linthorst¹  Jaap E. Klijn¹ 

[1] id="af1-ijms-06-00104">Physical Organic Chemistry Unit, Stratingh Institute University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherland

关键词: n-Decanol;    cetyl alcohol;    TritonX-100;    bilayers;    vesicles;    bilayer fragments;    decarboxylation;    6-NBIC;    solubilisation;    DSC;    cryo-EM;   

DOI  :  10.3390/i6010104

来源: mdpi

【 摘 要 】

The effects of n-decanol and cetyl alcohol incorporated into cationic di-n-hexa-decyldimethylammonium bromide (DHAB) bilayers on the packing and the resistance against solubilisation by Triton X-100 have been investigated. Solubilisation experiments revealed that the mismatch between the C₁₀-tail of n-decanol with the DHAB-tails does not affect the structural integrity of the vesicles. On the contrary, upon increasing amounts of cetyl alcohol, of which the tail matches in size with the DHAB-tails, breakdown of the vesicles is promoted, whereas complete solubilisation is strongly hampered. The system is further investigated by DSC and cryo-EM experiments. In addition, the effects of n-decanol and cetyl alcohol embedded into DHAB bilayers on the vesicular rate constants for the decarboxylation of 6-nitrobenzisoxazole-3-carboxylate (6-NBIC) suggest that both alcohols affect the structure of the Stern region in an equal manner, leading to a decrease in the catalysis. Therefore, it is concluded that addition of the alcohols leads to changes in properties of the interior of the bilayer, rather than the polar-apolar interface.

【 授权许可】

Unknown   
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