A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide

Molecules

Constantin I. Chiriac¹  Fulga Tanasa² 

[1] id="af1-molecules-10-00481">Institute of Macromolecular Chemistry “Petru Poni”, Aleea Grigore Ghica Voda 41 A, Iasi – 700487 Roman

关键词: Cinnamic acids;    direct synthesis;    boron tribromide/4-DMAP;    activating agent.;   

DOI  :  10.3390/10020481

来源: mdpi

【 摘 要 】

Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190°C) for 8-12 hours.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).