Formation of the Imidazolinone Ring Under Mild Conditions in the Presence of Sodium Hydride

Molecules

Aleksey N. Vasiliev¹  Antonio F. Lopez¹  Julio D. Fernandez¹ 

[1] Center for Chemical Research and Technologies, Cordoba Faculty, National Technological University, C.C. 17, Suc. 16, Cordoba 5016, Argentina

关键词: Imidazolinones;    herbicides;    cyclization;    sodium hydride;   

DOI  :  10.3390/90700535

来源: mdpi

【 摘 要 】

Substituted imidazolinones containing heterocyclic carboxylic acids as substituents and possessing herbicidal properties were synthesized by cyclization of 2-amino-2,3-dimethylbutyramide with heterocyclic ethyl dicarboxylates under mild conditions. The use of NaH as base leads to a significant increase in the reaction rate and allows the preparation of the target compounds in high yields.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.