Isomerization Reactions of Allylic Alcohols into Ketones with the Grubbs Reagent

Molecules

Katsuyuki Nakashima¹  Sanae Okamoto¹  Masakazu Sono¹ 

[1] id="af1-molecules-09-00541">Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan. Tel. [phone], Fax [phone]

关键词: Grubbs reagent;    allylic alcohol;    isomerization;    ketone;   

DOI  :  10.3390/90700541

来源: mdpi

【 摘 要 】

Allylic alcohols were isomerized into ketones by the action of the Grubbs reagent. Some model alcohols were prepared and tested under similar conditions to reveal that less substituted alkenes rearrange more easily. More hindered alcohols are stable under these conditions, however, the simple allylic alcohols tend to isomerize producing ethyl ketone and the corresponding degraded methyl ketone.

【 授权许可】

Unknown   
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