Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

Marine Drugs

Hideyuki Shigemori¹  Yuu Kasai¹  Kazusei Komatsu¹  Masashi Tsuda¹  Yuzuru Mikami² 

[1] Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan

关键词: marine-derived fungus;    Cladosporium sp.;    macrolide;    cytotoxic;   

DOI  :  10.3390/md204164

来源: mdpi

【 摘 要 】

Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa.

【 授权许可】

Unknown   
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