Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail” Approach

Molecules

Jie Shi¹  Mei-Yu Geng¹ 

[1] ¹Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, 5 Yushan Road, Qingdao 266003, P. R. China ²Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao 266011, P. R. China ³Tianjin Drug Institute, 38 Anshanxi Road, Tianjin, P. R. China

关键词: Cocktail approach;    enzymes;    drug safety evaluation.;   

DOI  :  10.3390/91100978

来源: mdpi

【 摘 要 】

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.