期刊论文详细信息
Molecules
Thermal Behaviour, Biological Activity and Conformational Study of a [Methoprene/β-Cyclodextrin] Complex in a Smoke Generating Formulation
Paola González Audino1  Hector Masuh2 
[1] id="af1-molecules-10-00534">Centro de Investigaciones de Plagas e Insecticidas, (CIPEIN-CITEFA/CONICET) J. B. De Lasalle 4397 (1603) Villa Martelli, Buenos Aires, Argenti
关键词: Methoprene;    β-cyclodextrin;    molecular modelling;    smoke generating formulation;    thermal stability.;   
DOI  :  10.3390/10030534
来源: mdpi
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【 摘 要 】

Methoprene, an insect growth regulator, was complexed with β-cyclodextrin, yielding a stable inclusion complex. TGA, X-ray powder diffraction and conformational analysis have been used to confirm the nature of this inclusion complex. The interaction between methoprene and β-cyclodextrin was investigated by means of Molecular Mechanics. The results account for the formation of a 1:1 inclusion complex stabilised by Van der Waals forces and hydrogen bonds. The [methoprene–β-cyclodextrin] complex included in smoke generating formulations and protected from thermal decomposition by the foaming agent azodicarbonamide was shown to be stable enough to release methoprene in fumes with good yields. The improved stabilty of the methoprene complex showed a correlation with increased biological activity against Musca domestica.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).

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