Molecules | |
Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene | |
关键词: Erythromycin; alkene; epoxidation; cycloaddition; pyrazoline; | |
DOI : 10.3390/11010121 | |
来源: mdpi | |
【 摘 要 】
The reactivity of the C12-21 alkene of some erythromycin A derivatives was studied. This double bond was easily oxidized to the corresponding epoxide with excellent stereoselectivity. A single crystal X-ray structure showed that the epoxide moiety was on the same side as the acetonide. When an erythromycin derivative containing a C12-21 alkene was treated with diazomethane a [3+2] cycloaddition affording a pyrazoline occurred. In the case of 6-
【 授权许可】
Unknown
© 2006 by MDPI (http://www.mdpi.org).
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Files | Size | Format | View |
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RO202003190059961ZK.pdf | 159KB | download |