Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region

Molecules

Mariusz Mojzych¹  Andrzej Rykowski¹ 

[1] Department of Chemistry, University of Podlasie, 3-Maja 54, Siedlce, Poland, PL-08-110, Tel.[phone], Fax [phone]

关键词: Pyrazolo[4;    3-e][1;    2;    4]triazines;    purine analogues;    enzyme inhibitors;   

DOI  :  10.3390/10101298

来源: mdpi

【 摘 要 】

Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with K_i values in the 10^-3 – 10^-5 M range.

【 授权许可】

Unknown   
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