Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes

Sensors

关键词: in-vivo voltammetry;    homovanillic acid;    HVA;    ascorbic acid;    uric acid;    diurnal changes;    haloperidol;    apomorphine;    dopamine release;    motor activity;    benzodiazepines;    food;    review;   

DOI  :  10.3390/s5060317

来源: mdpi

【 摘 要 】

This review focuses on the stability of voltammetric signals recorded over periods of months with carbon paste electrodes (CPEs) implanted in the brain. The key interaction underlying this stability is between the pasting oil and brain lipids that are capable of inhibiting the fouling caused by proteins. In brain regions receiving a significant dopaminergic input, a peak due to the methylated metabolites of dopamine, principally homovanillic acid (HVA), is clearly resolved using slow sweep voltammetry. Although a number of factors limit the time resolution for monitoring brain HVA concentration dynamics, the stability of CPEs allows investigations of long-term effects of drugs, as well as behavioral studies, not possible using other in-vivo monitoring techniques.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).