Towards a Synthesis of Vigabatrin Using Glycal Chemistry

Molecules

Sobhana B. Boga¹  Jaimala S. Aidhen¹ 

[1] id="af1-molecules-10-00871">Department of Chemistry, Indian Institute of Technology, Madras, Chennai-600 036, India, Tel. [phone], Fax [phone]

关键词: Vigabatrin;    GABA-T;    γ-aminobutyric acid;    4-amino-5-hexenoic acid;    Ferrier rearrangement;    glycal;   

DOI  :  10.3390/10080871

来源: mdpi

【 摘 要 】

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).