Mathematical Modeling of Biosensors Based on an Array of Enzyme Microreactors

Sensors

Romas Baronas¹  Feliksas Ivanauskas¹ 

[1] Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, 03225 Vilnius, Lithuania

关键词: Reaction-diffusion;    modeling;    biosensor;    microreactor;   

DOI  :  10.3390/s6040453

来源: mdpi

【 摘 要 】

This paper presents a two-dimensional-in-space mathematical model of biosensors based on an array of enzyme microreactors immobilised on a single electrode. The modeling system acts under amperometric conditions. The microreactors were modeled by particles and by strips. The model is based on the diffusion equations containing a non-linear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The model involves three regions: an array of enzyme microreactors where enzyme reaction as well as mass transport by diffusion takes place, a diffusion limiting region where only the diffusion takes place, and a convective region, where the analyte concentration is maintained constant. Using computer simulation, the influence of the geometry of the microreactors and of the diffusion region on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique.

【 授权许可】

Unknown   
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