QSAR of Some N1-Aryl/Heteroarylaminomethyl/ethyl-1,2,4-Triazoles Part II: Antimicrobial Activity Against Bacillus Subtilis

International Journal of Molecular Sciences

Vesna Dimova¹  Katica Colanceska Ragenovic² 

[1] Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, Ruger Boskovic 16, 1000 Skopje, Macedonia;id="af1-ijms-07-00119">1Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, Ruger Boskovic 16, 1000 Skopje, Macedon

关键词: QSAR/QSPR;    N¹-heteroarylamino/methyl/ethyl-1;    2;    4-triazole;    physico-chemical parameters;   

DOI  :  10.3390/i7040119

来源: mdpi

【 摘 要 】

QSAR analysis of a series of previously synthesized N¹-aryl-amino/methyl/ethyl-1,2,4-triazole and N¹-heteroarylamino/methyl/ethyl-1,2,4-triazole derivatives tested for growth inhibitory activity against Bacillus subtilis, was performed using the computer-assisted multiple regression procedure. Using the Hansch and Free Wilson approaches the activity contribution for either the aminomethyl/aminoethyl unit or the aromatic/heteroaromatic ring was determined from the correlation equation.

【 授权许可】

CC BY   
© 2006 by MDPI (http://www.mdpi.org).