Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

Molecules

Marko D. Mihovilovic¹  Thomas C. M. Fischer² 

[1] id="af1-molecules-11-00357">Vienna University of Technology – Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austr

关键词: Chain elongation;    β-ketoesters;    ethyl acetate;    heterocyclic esters;   

DOI  :  10.3390/11050357

来源: mdpi

【 摘 要 】

We present an easy method for the synthesis of β-ketoesters starting from various carbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain was introduced by a sequence involving α-deprotonation and quenching with CO₂, conversion to the corresponding acid chloride and subsequent chain elongation using deprotonated ethyl acetate.

【 授权许可】

Unknown   
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