Development of Fluorous Lewis Acid-Catalyzed Reactions

Molecules

Akihiro Yoshida¹  Xiuhua Hao¹  Osamu Yamazaki² 

[1] The Noguchi Institute, Itabashi-ku, Tokyo 173-0003, Japan; ^†;Asahi Kasei Corporation, Fuji, Shizuoka 416-8501, Japan

关键词: Fluorous chemistry;    Lewis acid;    sulfonimide;    biphasic system;    aqueous reaction;   

DOI  :  10.3390/11080627

来源: mdpi

【 摘 要 】

Organic synthetic methodology in the 21st century aims to conform to the principles of green sustainable chemistry (GSC) and we may expect that in the future, the realization of GSC will be an important objective for chemical industries. An important aim of synthetic organic chemistry is to implement waste-free and environmentally-benign industrial processes using Lewis acids as versatile as aluminum choride. A key technological objective of our work in this area has been to achieve a “catalyst recycling system that utilizes the high activity and structural features of fluorous Lewis acid catalysts”. Thus, we have developed a series of novel fluorous Lewis acid catalysts, namely the ytterbium(III), scandium(III), tin(IV) or hafnium(IV) bis(perfluoroalkanesulfonyl)amides or tris(perfluoro- alkanesulfonyl)methides. Our catalysts are recyclable and effective for acylations of alcohols and aromatics, Baeyer-Villiger reactions, direct esterifications and transesterifications in a fluorous biphasic system (FBS), in supercritical carbon dioxide and on fluorous silica gel supports.

【 授权许可】

Unknown   
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