Nucleoside Sensing

Sensors

Michael Fokkens¹  Frank-Gerrit Klärner² 

[1] Marburg University, Department of Chemistry, Hans-Meerwein-Strasse, 35032 Marburg, Germany. E-mail:;Duisburg-Essen University, Institute of Organic Chemistry, Universitätsstr. 5, 45117 Essen, Germany. E-mail:

关键词: Nucleoside;    Nucleotide;    Molecular Clip;    π-Stacking;    NMR Sensing;   

DOI  :  10.3390/s6080860

来源: mdpi

【 摘 要 】

A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the ¹H NMR spectrum. Nucleoside drugs can therefore be detected with high selectivity in the presence of their phosphorylated pendants or nucleic acids.

【 授权许可】

Unknown   
2006 by MDPI (http://www.mdpi.org).