Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

Molecules

Fatima-Zohra Zradni²  Jack Hamelin¹ 

[1] Groupe d'Ingénierie Chimique et Molécules pour le Vivant 3(ICMV3)-UMR 6226, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France; E-mail:;Faculté des Sciences, Département de Chimie, Université d’Es-sénia, Oran, B.P 1524, Algeria; ^†E‑Mail:

关键词: Medium-sized ring lactams;    imine alkylation;    Schiff bases;    microwave irradiation;   

DOI  :  10.3390/12030439

来源: mdpi

【 摘 要 】

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.

【 授权许可】

Unknown   
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