Proteasome and NF-κB Inhibiting Phaeophytins from the Green Alga Cladophora fascicularis

Molecules

Xinping Huang²  Min Li²  Bo Xu²  Xiaobin Zhu¹  Zhiwei Deng³ 

[1] Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.R. China;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P.R. China, Tel: [phone]; Fax: [phone];Analytic and Testing Center, Beijing Normal University, Beijing 100073, P.R. China

关键词: Green alga;    Cladophora fascicularis;    porphyrinolactone;    NF-κB;    proteasome;   

DOI  :  10.3390/12030582

来源: mdpi

【 摘 要 】

Chemical examination of the green alga Cladophora fascicularis resulted in the isolation and characterization of a new porphyrin derivative, porphyrinolactone (1), along with five known phaeophytins 2-6 and fourteen sterols and cycloartanes. The structure of 1 was determined on the basis of spectroscopic analyses and by comparison of its NMR data with those of known phaeophytins. Compounds 1-6 displayed moderate inhibition of tumor necrosis factor alpha (TNF-α) induced nuclear factor-κB (NF-κB) activation, while 2 and 4 displayed potential inhibitory activity toward proteasome chymotripsin-like activation. The primary structure-activity relationship was also discussed.

【 授权许可】

Unknown   
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