A New Tiapride Selective Electrode and Its Clinical Application

Sensors

Joaquín A. Ortuño¹  Vicente Rnas¹  Mª Soledad Garc໚¹  Mª Isabel Albero¹ 

[1] id="af1-sensors-07-00400">Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spai

关键词: Ion-selective electrode;    tiapride determination;    urine;    iontophoresis solution;   

DOI  :  10.3390/s7030400

来源: mdpi

【 摘 要 】

The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB^-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10^-5-1x10^-2 M) with a slope of 57.5±0.2 mV dec^-1 of concentration, a detection limit of 4.3x10^-6±2.5x10^-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution.

【 授权许可】

Unknown   
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