期刊论文详细信息
Molecules | |
Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives | |
Fu-Min Zhang1  Xiao-Jun Yao1  Xuan Tian1  | |
[1] State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China. Tel: (+86) 931-8912410; Fax: (+86) 931-8912582; E-mails: † | |
关键词: -Demethylepipodophyllotoxin"'>4'-Demethylepipodophyllotoxin; 5-fluorouracil; anticancer activities; partition coefficients; | |
DOI : 10.3390/11110849 | |
来源: mdpi | |
【 摘 要 】
A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior
【 授权许可】
Unknown
© 2006 by MDPI (http://www.mdpi.org).
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