Dinuclear Zinc (II) Complexes of Macrocyclic Polyamine Ligands Containing an Imidazolium Bridge: Synthesis, Characterization, and Their Interaction with Plasmid DNA

International Journal of Molecular Sciences

Jun Huang¹  Qing-Dong Huang¹  Ji Zhang¹  Li-Hong Zhou¹  Qiang-Lin Li¹  Kun Li¹  Ning Jiang²  Hong-Hui Lin²  Jiang Wu¹ 

[1] Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, 610064, P. R. China;Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, Sichuan, 610064, P. R. China

关键词: 1;    4;    7;    10-tetraazacyclododecane (cyclen);    zinc (II) complexes;    imidazolium;    synthesis;    DNA protection;   

DOI  :  10.3390/i8070606

来源: mdpi

【 摘 要 】

Two novel macrocyclic polyamine ligands and their dinuclear zinc (II) complexes were synthesized and characterized. Their interaction with plasmid DNA was studied by gel electrophoresis and fluorescence quenching experiment. The result showed that these complexes could bind DNA efficiently under physiological conditions.

【 授权许可】

Unknown   
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