Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface

Sensors

Joaquin A. Ortuño¹ 

关键词: Interface between Two Immiscible Electrolyte Solutions;    ion amperometry;    plasticized polymeric membrane;    tacrine determination;    flow-injection analysis;   

DOI  :  10.3390/s7071185

来源: mdpi

【 摘 要 】

A flow-injection pulse amperometric method for determining tacrine, based on ion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. A four-electrode potentiostat with ohmic drop compensation was used, while a flow-through cell incorporated the four electrodes and the membrane, which contained tetrabutylammonium tetraphenylborate. The influence of the applied potential and of the flow-injection variables on the determination of tacrine was studied. In the selected conditions, a linear relationship between peak height and tacrine concentration was found up to 4×10^-5M tacrine. The detection limit was 1×10^-7M. Good repeatability was obtained. Some common ions and pharmaceutical excipients did not interfere.

【 授权许可】

Unknown   
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