Heterocycles [h]Fused onto 4-Oxoquinoline-3-Carboxylic Acid, Part IV. Convenient Synthesis of Substituted Hexahydro [1,4]Thiazepino[2,3-h]quinoline-9-carboxylic Acid and Its Tetrahydroquino[7,8-b]benzothiazepine Homolog †

Molecules

Mohammed H. Al-Huniti¹  Mustafa M. El-Abadelah¹  Jalal A. Zahra¹  Salim S. Sabri² 

[1] Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan; E-mails:;University of Sharjah, Sharjah, P. O. Box 27272, United Arab Emirates (UAE); E-mail:

关键词: 7-Chloro -8-nitro-4-oxoquinoline-3-carboxylic acid;    3-mercaptopropanoic acid;    2-mercaptobenzoic acid;    S_N-Ar reaction;    lactamization;   

DOI  :  10.3390/12081558

来源: mdpi

【 摘 要 】

Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylic acid 3 is prepared by PPA-catalyzed thermal lactamization of the respective 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylic acid 9. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionic acid with 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-1,4-dihydroquinoline-3-carboxylic acid 7 in the presence of triethylamine. A benzo-homolog of 3, namely tetrahydroquino[7,8-b]benzothiazepine-3-carboxylic acid 6, is analogously prepared via the raction of 2-mercaptobenzoic acid with 7, followed by reduction of the resulting 7-[(2-carboxyphenyl)thio]-8-nitro product 10 into the corresponding 8-amino derivative 11, and subsequent lactamization. The structures assigned to 3, 6 and 8-11 are based on microanalytical and spectral (IR, MS, NMR) data.

【 授权许可】

Unknown   
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