Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator

Molecules

Kamil Musilek²  Kamil Kuca²  Vlastimil Dohnal²  Daniel Jun²  Jan Marek¹ 

[1] Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic;Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

关键词: Quaternary;    alkylation;    acetylcholinesterase;    reactivator;    oxime;    nerve agents;   

DOI  :  10.3390/12081755

来源: mdpi

【 摘 要 】

The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.

【 授权许可】

Unknown   
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