Synthesis and Antimicrobial Activity of Some New1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

Molecules

Otilia Pintilie¹  Lenuta Profire³  Valeriu Sunel¹  Marcel Popa² 

[1] Department of Organic Chemistry and Biochemistry and ⁴ Department of Inorganic Chemistry; Faculty of Chemistry, “Al. I. Cuza” University, Bd. Carol I, no. 11, 700506 Iasi, Romania;Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering, “Gh. Asachi” Technical University, Bd. Mangeron, no. 71A, 700050, Iasi, Romania;;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Gr. T. Popa” Medicine and Pharmacy University, Universitatii Street, no. 16, 700115 Iasi, Romania

关键词: 1;    3;    4-Thiadiazole;    1;    2;    4-triazole;    thiosemicarbazide;    D;    L-methionine;    antimicrobial activity;   

DOI  :  10.3390/12010103

来源: mdpi

【 摘 要 】

New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.

【 授权许可】

Unknown   
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