Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin

International Journal of Molecular Sciences

Jing Zhao²  Xiaofeng Zheng²  Wei Xing²  Junyi Huang¹ 

[1] School of Life Science and Shanghai Key Laboratory of Bio-Energy Crops, Shanghai University, Shanghai 200444, P. R. China;Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China

关键词: Camptothecin;    human serum albumin;    cyclic voltammetry;   

DOI  :  10.3390/i8010042

来源: mdpi

【 摘 要 】

Camptothecin, an anticancer component from Camptotheca acuminate, may interact with human serum albumin (HSA) at the subdomain IIA (site I), and then convert to its inactive form(carboxylate form). In this paper, the detailed electrochemical behaviors of camptothecin at a pyrolytic graphite electrode is presented. The interaction between camptothecin and HSA is also studied by electrochemical technique. By comparing with bovine serum albumin (BSA), which is highly homologous to HSA, we prove that camptothecin can specifically bind to HSA. Meanwhile, the inhibitory influence of sodium salicylate to this binding is also discussed.

【 授权许可】

Unknown   
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