Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method

Molecules

Yoshinori Kadoma³  Toshiko Atsumi²  Norihisa  Okada²  Mariko Ishihara²  Ichiro Yokoe¹ 

[1] Faculty of Pharmaceutical Sciences, Josai University, Saitama 3500295, Japan; E-mail:;Meikai Unversity School of Dentistry, Sakado, Saitama 3500283, Japan; E-mails:;Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan; E-mail:

关键词: Radical-scavenging activity;    natural and synthetic methoxyphenols;    DPPH;    BPO;    AIBN;    induction method;   

DOI  :  10.3390/12020130

来源: mdpi

【 摘 要 】

The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X-phenol (X=NO₂, Cl, Br, OCH₃, COCH₃, CH₃, t-(CH₃)₃, C₆H₅) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2'-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2‑Allyl-4-methoxyphenol and 2,4-dimethoxy-phenol scavenged not only oxygen-centered radicals (PhCOO^.) derived from BPO, but also carbon-centered radicals (R^.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity

【 授权许可】

Unknown   
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