Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus

Molecules

Naoko Togashi¹  Akiko Shiraishi¹  Miki Nishizaka¹  Keisuke Matsuoka²  Kazutoyo Endo²  Hajime Hamashima³ 

[1] Department of Microbiology, Showa Pharmaceutical University, Machida, 194-8543 Tokyo, Japan;Department of Physical Chemistry, Showa Pharmaceutical University, Machida, 194-8543 Tokyo, Japan;Laboratory of Bio-Medicinal Pharmacology, Showa Pharmaceutical University, Machida, 194-8543 Tokyo, Japan

关键词: Staphylococcus aureus;    fatty alcohols;    antibacterial activity;    length of carbon chain;    K⁺ ion leakage;   

DOI  :  10.3390/12020139

来源: mdpi

【 摘 要 】

The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org).