Microwave-Assisted Synthesis of Phenothiazine and Quinoline Derivatives

International Journal of Molecular Sciences

Luiza Găină²  Castelia Cristea²  Claudia Moldovan²  Dan Porumb²  Emanoil Surducan⁴  Călin Deleanu³  Abdalah Mahamoud¹  Jacques Barbe¹ 

[1] Universitée de la Mediteranée, Faculté de Pharmacie, Marseille CEDEX 5, E-mail:;“Babeş-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Organic Chemistry Department, Cluj-Napoca-Ro, E-mail:;Institute of Organic Chemistry, National NMR Laboratory, Bucharest-Ro. E-mail:;INCDTIM-Cluj-Napoca-Ro, E-mail:

关键词: MAOS;    Quinoline;    Pyrido[3;    2-g]quinoline;    Phenothiazine;    formylation;   

DOI  :  10.3390/i8020070

来源: mdpi

【 摘 要 】

Application of a dynamic microwave power system in the chemical synthesis of some phenothiazine and quinoline derivatives is described. Heterocyclic ring formation, aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensation reactions were performed on solid support, or under solvent free reaction conditions. The microwave-assisted Duff formylation of phenothiazine was achieved. Comparison of microwave-assisted synthesis with the conventional synthetic methods demonstrates advantages related to shorter reaction times and in some cases better reaction yields.

【 授权许可】

Unknown   
© 2007 by MDPI