Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines

Molecules

Xiang-Lin Zhao¹  Yan-Fang Zhao¹  Shu-Chun Guo²  Hai-Sheng Song²  Ding Wang² 

[1] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China; Fax: [phone], Phone: [phone]; E-mails: ^†;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China; Fax: [phone], Phone: [phone]; E-mails: ^†

关键词: [1;    2;    4]Triazolo[1;    5-a]pyrimidines;    Synthesis;    antitumor activities;   

DOI  :  10.3390/12051136

来源: mdpi

【 摘 要 】

In order to find novel anti-tumor compounds a series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized. The structures of all the compounds were confirmed by IR, ¹H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested in vitro by the MTT method. Among them, compound 19 displayed the best anti-tumor activity, with IC₅₀ values of 12.3 μM and 6.1 μM against Bel-7402 and HT-1080 cell lines, respectively.

【 授权许可】

Unknown   
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